在办公室工作者的血压上减少久坐行为的影响:RESET-BP随机临床试验的结果
Bethany Barone Gibbs1, Subashan Perera2, Kimberly A Huber3
1Department of Epidemiology and Biostatistics (B.B.G.), West Virginia University, Morgantown.
Circulation
|August 21, 2024
概括
减少3个月的静坐行为并没有降低办公室工作者的血压或脉冲波速度. 然而,工作时间SB的减少与腹筋血压的降低有关,而PWV与PWV的关联因时间而异.
科学领域:
- 心血管健康
- 职业健康问题
- 运动生理学
背景情况:
- 久坐不动行为 (SB) 与心血管疾病风险有关,但随机试验的因果证据有限.
- 之前的观察研究表明静坐时间与血压升高和脉冲波速度之间存在联系.
研究的目的:
- 调查办公室工作者的静坐行为是否可以降低血压和脉冲波速率.
- 测试一种假设,即3个月的干预旨在减少SB会导致心血管标志物的改善.
主要方法:
- 一项为期3个月的随机临床试验,涉及271名血压升高的办公室工作者 (年龄18至65岁),随机分为SB降低干预或对照组.
- 干预组每天使用站立和步行,使用辅导,活动提示和坐立桌子取代了2-4小时的SB.
- 血压 (BP) 和脉冲波速率 (PWV) 在基线和3个月使用加速度计和临床评估进行测量.
主要成果:
- 这项干预措施成功地减少了每日约1.15小时的站立时间,主要是在工作时间,但低于目标.
- 在休息时的缩血压,腹缩血压,24小时的门诊血压或PWV中没有观察到显著的群体间差异.
- 工作时间下降的SB与休息时间下降的透气压相关,而工作时间站立与PWV有不利的关联;非工作时间站立显示出有利的关联.
结论:
- 减少工作时间的久坐行为和增加站立的3个月的干预措施在降低血压或PWV方面无效.
- 未来的研究应该探索超越工作时间站立的SB减少策略,并澄清站立在工作期间与非工作期间对PWV的差异影响.
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