皮下治疗与静脉注射infliximab治疗 - 一项现实研究:朝着更高的药物度迈进
Ana Isabel Ferreira1,2,3, Tiago Lima Capela1,2,3, Cátia Arieira1,2,3
1Gastroenterology Department, Hospital Senhora da Oliveira - Guimarães, Guimarães.
在炎症性肠病 (IBD) 患者中,切换为皮下注射因弗利西马布 (SC-IFX) 维持了临床缓解. 这种转变导致了更高的INFLIXIMAB血清度,而不会影响疗效或安全.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 皮下注射的infliximab (SC-IFX) 与静脉注射的infliximab (IV-IFX) 相比,在炎症性肠病 (IBD) 中提供了更好的药理动力学和免疫学特征.
- SC-IFX已经证明了与IV-IFX相似的疗效和安全性.
研究的目的:
- 评估从IV-IFX切换到SC-IFX的IBD患者的临床,生化和药理结果.
- 在已经处于临床缓解状态的患者中,评估6个月的随访期内的结果.
主要方法:
- 一项回顾性队列研究包括41名IV-IFX临床缓解的IBD患者,他们转换为SC-IFX (120毫克每隔一周).
- 在切换前和6个月后评估的生物化学参数,包括infliximab血清度,ESR,CRP和便calprotectin.
主要成果:
- 所有41名患者 (32名克罗恩病,9名性结肠炎) 在切换后6个月保持了临床缓解.
- 治疗持续率为100%,无需使用皮质类固醇或重新切换到IV-IFX.
- 平均infliximab血清度显著增加 (17.3±6.6比9.1±5.5μg/ml,P<0.001),而ESR,CRP和便calprotectin没有显著变化.
- 没有一个患者对infliximab产生抗体.
结论:
- 从IV-IFX切换到SC-IFX对于临床缓解的IBD患者是有效的.
- SC-IFX导致因弗利西马布的血清度更高.
- 切换是有效的,无论同时免疫调节疗法.
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