多酶模拟MoCu双原子纳米酶触发氧化应激级联放大,用于高效的协同作用的癌症治疗
Ziyao Li1,2, Binbin Ding1, Jing Li1,2
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Angewandte Chemie (International ed. in English)
|August 21, 2024
概括
这项研究引入了一种新型的双原子纳米酶,通过产生反应性氧物种和耗尽抗氧化剂来增强癌症治疗. 这种多酶模拟方法改善了氧化应激放大,以获得更好的治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 由于高原子效率,单原子纳米酶 (SAzymes) 在反应性氧物种 (ROS) 介导的癌症治疗中表现有前途.
- 挑战包括高反应能量障碍和瘤微环境抗氧化剂,限制治疗疗效.
研究的目的:
- 开发一种模仿多酶的双原子纳米酶 (DAzyme),用于增强癌症治疗.
- 调查MoCu DA酶的协同催化活动和治疗潜力.
主要方法:
- 合成了一种铜双原子纳米酶 (MoCu DAzyme),具有过氧化酶,氧化酶,谷氨氧化酶和NADPH氧化酶模仿活动.
- 评估了催化活动,ROS生成,抗氧化剂耗尽和光热转化.
- 评估了结合催化和光热疗法的协同治疗癌症的疗效.
主要成果:
- 与MoSAzyme相比,MoCu DAzyme表现出增强的基质吸附和降低的能量障碍.
- DAzyme有效地产生了多个ROS,耗尽的谷氨 (GSH),并抑制了其再生.
- 在近红外II窗口中,MoCu DAzyme表现出显著的光热转换.
- 通过联合催化和光热疗法实现了高效的协同治疗癌症.
结论:
- MoCu DAzyme在癌症治疗中提供了卓越的催化活性和治疗潜力.
- 双原子设计和多酶模拟有效地放大氧化应激并提高治疗结果.
- 这项工作推进了DAzyme的应用,并提供了对纳米催化剂癌症治疗的见解.
更多相关视频
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.1K
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.7K
相关概念视频
01:46Electron Transport Chain: Complex I and II
12.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
12.4K
01:22Amplifying Signals via Enzymatic Cascade
8.4K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.4K