更年期血管运动症状和亚临床动脉样性心血管疾病:基于人口的研究
Sigrid Nilsson1, Angelika Qvick2, Moa Henriksson1
1Department of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences Linköping University Linköping Sweden.
Journal of the American Heart Association
|August 21, 2024
概括
严重的更年期血管运动症状 (VMS) 与女性冠状动脉样硬化有关. 这种关联与VMS的长期或早期发病更为强烈,独立于其他风险因素.
科学领域:
- 心血管健康 心血管健康
- 绝经研究 绝经研究
- 医学诊断 医学诊断 医学诊断
背景情况:
- 更年期的血管运动症状 (VMS) 越来越多地被认为是潜在的心血管风险因素.
- 在亚临床动脉样硬化心血管疾病中VMS的确切作用尚不清楚.
- 这项研究调查了更年期妇女的VMS和亚临床动脉样硬化之间的关联.
研究的目的:
- 评估血管运动症状 (VMS) 和亚临床动脉样性心血管疾病之间的关联.
- 为了确定VMS的严重程度,持续时间或发病是否会影响心血管风险.
- 评估VMS作为前期和绝经后妇女心血管疾病的潜在指标.
主要方法:
- 对2995名年龄在50-64岁之间的女性进行了横截面研究.
- 收集关于VMS严重程度,持续时间和发病的问卷调查数据.
- 亚临床动脉样硬化评估使用冠状动脉计算机断层扫描血管造影,冠状动脉分数和带超声波.
主要成果:
- 曾经严重的VMS与通过计算机断层扫描血管学检测到的冠状动脉样硬化有显著的关联 (OR, 1.33).
- 持续超过5年或早期发作的严重VMS显示出更强的关联 (OR分别为1.50和1.66).
- 没有发现与冠状动脉分数>100或冠状动脉斑块有显著的关联.
结论:
- 严重的VMS,独立于其他风险因素,与亚临床冠状动脉样硬化有关.
- 严重的VMS的长期持续或早期发作会放大这种关联.
- 在这个队列中,中度的VMS与亚临床动脉样硬化没有显著的关联.
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