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Updated: Jun 16, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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第三类CRISPR蛋白酶CalpL的SAVED域是一个环核酶

Sophie C Binder1, Niels Schneberger1, Maximilian Schmitz1

  • 1Institute of Structural Biology, Venusberg-Campus 1, University of Bonn, Bonn, Germany.

Nucleic acids research
|August 21, 2024
PubMed
概括

克里斯普尔-卡斯系统使用循环橄基酸盐 (cOA) 进行防御. 这项研究揭示了CalpL蛋白酶中SAVED域降解COA,调节CRISPR-Cas免疫反应并帮助细胞恢复.

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