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Updated: Jun 15, 2026

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
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对粘膜层莱什曼病的治疗方法的成本效益研究

Janaína de Pina Carvalho1, Gláucia Cota1, Mariana Lourenço Freire1

  • 1Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brasil.

Cadernos de saude publica
|August 21, 2024
PubMed
概括

这项研究评估了巴西粘膜层莱什曼病治疗的成本效益. 梅格胺抗酸和氧菲林的组合非常具有成本效益,而米尔特福辛则非常具有成本效益.

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
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Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...