营养,GH/IGF-1信号传递,以及癌症
1Longevity Institute, Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, California, USA.
Endocrine-related cancer
|August 21, 2024
概括
营养和禁食策略,包括卡路里限制 (CR) 和间歇性禁食 (IF),可以帮助预防癌症. 这些饮食干预措施可能通过调节生长激素 (GH) 和类似胰岛素的生长因子-I (IGF-1) 信号通路来起作用.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 癌症是全球主要的死亡原因,由于生活方式和人口因素,癌症发病率上升.
- 营养和禁食显示出减轻癌症风险和与年龄有关的疾病的潜力.
- 卡路里限制 (CR),间歇性禁食 (IF),周期性禁食 (PF) 和模仿禁食的饮食 (FMDs) 在动物模型中证明了益处.
研究的目的:
- 审查营养和各种禁食方法在预防癌症中的作用.
- 探索调节生长激素 (GH) /胰岛素类生长因子-I (IGF-1) 信号传递调节这些效应的假设.
- 检查激素水平交替对寿命和功能的影响.
主要方法:
- 关于与癌症和衰老相关的营养,CR,IF,PF和口病研究的文献综述.
- 专注于研究GH/IGF-1轴和胰岛素信号通路的研究.
- 分析来自动物研究和新出现的人类数据的数据.
主要成果:
- CR,IF,PF和口病在改善动物健康,寿命和预防癌症方面表现有前途.
- 这些饮食干预措施对衰老和癌症的影响部分是由减少GH/IGF-1轴活性介导的.
- 交替低水平和正常水平的GH,IGF-1和胰岛素可以优化寿命和功能.
结论:
- 像CR和禁食这样的饮食干预措施可以在癌症预防中发挥作用.
- 调节GH,IGF-1和胰岛素信号通路是这些预防作用的关键机制.
- 对最佳饮食模式和荷尔蒙波动的进一步研究对于长寿和癌症预防是有必要的.
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