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甲状腺功能,甲状腺疾病和原发性阿尔多斯特主义之间的关联.
Mayire Maiturouzi1, Qing Zhu1, Delian Zhang1
1Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, People's Republic of China.
原发性阿尔多斯特隆症 (PA) 与较低的甲状腺功能和甲状腺结节的更高患病率有关. 建议PA患者进行甲状腺问题的查.
科学领域:
- 内分泌学 在内分泌学.
- 高血压研究 高血压研究
- 甲状腺学 甲状腺学
背景情况:
- 之前关于原发性阿尔多斯泰隆症 (PA) 和甲状腺疾病的研究产生了相互矛盾的结果.
- 了解甲状腺功能,甲状腺疾病和PA之间的关系对于患者管理至关重要.
研究的目的:
- 研究甲状腺功能,甲状腺疾病和PA,包括其亚型之间的关联.
- 为了比较PA患者的甲状腺健康与基本高血压 (EH).
主要方法:
- 一项涉及1023名PA患者和6138名EH患者的横截面研究.
- 通过上腺静脉采样 (AVS),PA患者被分为产生阿尔多斯特的腺瘤 (APA) 和异常性阿尔多斯特症 (IHA).
- 多变量逻辑回归分析了甲状腺参数,甲状腺结节和PA亚型之间的关系.
主要成果:
- 与EH患者相比,PA患者的自由甲状腺素 (FT4),自由三甲状腺素 (FT3),总甲状腺素 (TT4) 和总三甲状腺素 (TT3) 水平较低.
- 甲状腺瘤患者及其亚型的甲状腺瘤患病率高 (PA: 56.10%) 比EH患者 (48.90%).
- PA (调整的OR: 1.290) 和IHA (调整的OR: 1.316) 与甲状腺结节有显著的相关性;更高的血阿尔多素度 (PAC) 与增加的结节患病率相关.
结论:
- 原发性阿尔多斯特龙症患者的甲状腺功能下降,甲状腺结节的患病率增加.
- 对于被诊断患有PA的人来说,建议进行常规的甲状腺功能和结节查.
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