家庭地中海热病患者关节炎的特征
Selcan Yenigun1, Ali Yagiz Ayla2, Mebrure B Yuzbasioglu1
1Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
有关节炎的家族地中海热病 (FMF) 患者表现出更高的疾病活性和抗素耐药性. M694V突变与增加的圣炎和脊髓关节炎有关,这表明共享的疾病途径.
科学领域:
- 类风湿病学 类风湿病学
- 遗传学 是一个遗传学.
- 内部医学 内部医学
背景情况:
- 家庭地中海热 (FMF) 经常伴有关节炎.
- 在FMF患者中,关节炎的特征可以显著变化.
研究的目的:
- 在被诊断为家族地中海热病的患者中鉴定关节炎的特征.
- 为了确定FMF群体中关节炎的特定特征和结果.
主要方法:
- 在2005年至2020年期间,对患有关节炎的FMF患者进行了回顾性分析.
- 数据收集包括人口统计学,遗传学,攻击特征,并发病症和治疗反应.
主要成果:
- 在40%的FMF患者 (954/2350) 中观察到关节炎.
- 患有关节炎的患者出现症状较早,M694V突变频率较高,抗素耐药性增加.
- 单关节模式更为常见,而生物制剂的使用在这个队列中更高.
结论:
- 患有关节炎的FMF患者表现出高的疾病活性,通常与M694V突变有关.
- 在M694V携带者中增加的圣炎和脊髓关节炎表明了常见的致病机制.
- 在FMF流行地区的关节炎,在差异诊断中需要考虑FMF.
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