在痴呆症患者的潜在不适当药物使用中存在种族和种族差异
Carolyn W Zhu1,2,3, Justin Choi4, William Hung1,2
1Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of the American Geriatrics Society
|August 21, 2024
概括
在患有痴呆症的老年人中,在潜在不合适的药物 (PIM) 使用方面存在种族和种族差异. 与白人相比,黑人,西班牙裔和亚洲裔参与者表现出不同的PIM暴露模式.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 健康差异 在健康上的差异
背景情况:
- 在老年痴呆症患者中使用可能不合适的药物 (PIM) 的种族和种族差异尚未得到充分理解.
- 了解这些差异对于在痴呆症管理中提供公平护理至关重要.
研究的目的:
- 在被诊断患有痴呆症的老年人中调查PIM使用的种族和民族差异.
- 分析基于种族和种族的各种药物类别中PIM暴露的差异.
主要方法:
- 利用来自国家阿尔茨海默氏症协调中心统一数据集 (NACCUDS) 的60岁以上痴呆症参与者的数据.
- 应用了2019年美国老年病学学会的Beers标准来识别PIM.
- 采用后勤,Poisson,负二项式和通用线性模型来评估种族/种族和PIM使用之间的关联,药物总数和抗胆固醇负担.
主要成果:
- 与白人参与者相比,黑人,西班牙裔和亚洲裔参与者总体上服用的药物总量较少.
- 亚洲参与者不太可能使用任何PIM.
- 与白人参与者相比,黑人参与者使用二类药物和抗抑郁药物较少,但使用抗精神病药物,心血管药物和骨肌肉放松剂较多.
- 西班牙裔参与者使用肌松剂的比例更高,抗胆固醇负担更低.
- 亚洲参与者使用的二类药物较少.
结论:
- 在获得专家护理的痴呆症患者中,在PIM暴露和特定药物类别中观察到显著的种族和种族差异.
- 这些发现表明,PIM使用的差异可能在一般人群中更加明显.
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