在人类肠道微生物群中,假定含的一氧化碳脱酶编码 prokaryotes 的遗传学多样性
Yuka Adachi Katayama1, Ryoma Kamikawa1, Takashi Yoshida1
1Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan.
Microbial genomics
|August 21, 2024
概括
人的肠道微生物群包含多种能够通过含的CO脱酶 (pCODH) 利用一氧化碳 (CO) 的 prokaryotes. 这些微生物可能会使用二氧化碳进行生物合成,而不是去除,影响肠道生态系统.
科学领域:
- 微生物学 微生物学
- 转基因组学是指转基因组学.
- 人类肠道微生物组
背景情况:
- 人体产生一氧化碳 (CO),但在肠道中以前只知道两种利用CO的核细胞.
- 这些利用二氧化碳的微生物的遗传学多样性和代谢作用在很大程度上是未知的.
研究的目的:
- 研究人类肠道微生物群中使用CO的核细胞的多样性和分布.
- 描述涉及这些细菌利用二氧化碳的基因和途径.
主要方法:
- 对超过一千个代表性的人类肠道微生物基因组进行生物信息分析,以识别含CO脱酶 (pCODH) 的基因.
- 对公共元转录组数据集的分析,以确认pCODH基因在人类肠道中的表达.
- 检查相关基因,包括木-Ljungdahl通路 (WLP) 和其他代谢功能的基因.
主要成果:
- 确定了编码pCODH的1000多个基因组,将已知的分类学扩展到8个类,82个属和248个物种.
- 在97.3%的健康人体便样本中发现了pCODH转录,这表明存在广泛.
- 许多编码pCODH的基因组具有部分的伍德-Ljungdahl路径,这表明了CO固定的退化基因组,并且缺乏CO氧化呼吸的基因.
结论:
- 人的肠道微生物组包含大量,以前未被识别的利用CO的细胞核生物的多样性.
- 这些 prokaryotes 很可能利用一氧化碳进行生物合成或固定,而不是用于排毒.
- 这些发现突出了这些微生物在人类肠道微生物生态系统和碳循环中的潜在作用.
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