氧化酸化不违反热力学第二定律
1Department of Chemistry (emeritus), Willamette University, Salem, Oregon 97301,United States.
The journal of physical chemistry. B
|August 21, 2024
概括
线粒体的氧化酸化并不违反热力学第二定律. 重新评估关键值和膜结构表明,李的说法没有得到当前科学证据的支持.
科学领域:
- 生物化学 生物化学
- 热力学是一种热力学.
- 细胞呼吸 细胞呼吸
背景情况:
- 詹姆斯·李 (James W. Lee) 提出,线粒体的氧化酸化违反了热力学第二定律.
- 李将这种涉嫌违规归因于涉及横向和纵向膜不对称的"B型"过程.
研究的目的:
- 批判性地评估李关于热力学第二定律和氧化酸化的说法.
- 提出科学准确的解释热力学原理在细胞能源生产.
主要方法:
- 重新分析基布斯自由能量对氧化还原反应 (ΔGredox) 和ATP合成 (ΔGATP合成) 的文献值.
- 对质子 (I,III和IV组件) 的最新结构数据的检查.
- 评估李对生物能膜表面的质子度 (ΔpHsurface) 的预测.
主要成果:
- 修正后的热力学值表明,氧化酸化过程中不会违反热力学第二定律.
- 目前的结构数据不支持质子中纵向膜不对称的存在.
- 李预测的表面质子度 (ΔpHsurface) 可能由于方法错误而被高估.
结论:
- 关于线粒体氧化酸化违反热力学第二定律的说法没有得到强有力的实验或理论证据的支持.
- 既定的热力学原理和当前的结构生物学发现与氧化酸化相一致.
- 李关于膜不对称性和质子梯度的具体说法受到可靠数据的挑战.
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