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Updated: Jun 16, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
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Published on: March 12, 2019

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优化了测量化学物质与甲状腺激素分发蛋白 transthyretin 和甲状腺素结合球蛋白的竞争性结合的方法

Yang Shen1, Toine F H Bovee2, Douwe Molenaar3

  • 1Wageningen Food Safety Research (WFSR), Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, The Netherlands.

Archives of toxicology
|August 21, 2024
PubMed
概括

对甲状腺激素 (TH) 结合蛋白 transthyretin (TTR) 和甲状腺素结合环球蛋白 (TBG) 进行了新的测定. 这些方法有效地选化学物质,揭示了PFOS和PFOA等化合物的明显结合差异.

关键词:
光的两极化是因为光.和多醇基物质是多和多的.在TBG中具有约束力.有关TTR的约束性甲状腺激素系统的破坏者

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Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
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The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
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