探索肺部参与新诊断的类风湿性关节炎和牛皮性关节炎:一个单一中心研究
Valentin Sebastian Schäfer1, Lone Winter1, Dirk Skowasch2
1Department of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital Bonn, Bonn, Germany.
Rheumatology international
|August 21, 2024
概括
新型风湿性关节炎 (RA) 和牛皮性关节炎 (PsA) 患者的肺部感染很常见,通常没有症状. 早期查对于及时检测和治疗关节炎中的肺部问题至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 放射学 放射学是指放射学
背景情况:
- 类风湿性关节炎 (RA) 和牛皮性关节炎 (PsA) 是一种全身性自身免疫性疾病.
- 肺部干扰是已知的RA和PSA的关节外表现.
- 早期发现肺部并发症对于患者的治疗结果至关重要.
研究的目的:
- 确定新诊断的,未经治疗的RA和PsA患者中肺部参与的患病率和特征.
- 为了确定与肺部干扰相关的风险因素.
- 评估用于查肺部干扰的诊断工具.
主要方法:
- 对50名新诊断的,未经治疗的RA和PsA患者和26名对照者的横截面研究.
- 多模式诊断方法,包括临床评估,肺功能测试和胸部放射.
- 分析呼吸道症状,呼吸幅度,肺功能和X光学发现.
主要成果:
- 36%的关节炎患者有呼吸道症状,而对照组只有11.5%.
- 64%的关节炎患者的呼吸宽度有所减少,而对照组的这一比例为23.1%.
- 胸部放射检查显示,有37%的关节炎患者 (50%的RA,22.7%的PsA) 患有肺部感染,其中64.7%无症状. 晚年和类风湿因子水平是相关的危险因素.
结论:
- 在新诊断的RA和PsA中,肺部干扰很普遍,并且往往无症状.
- 早期,多学科的查是必不可少的,特别是在高风险患者.
- 需要进一步的研究来开发用于早期检测和治疗的全面查方案.
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