确定暴露于极端温度和先天性心脏病的关键窗口
Huanhuan Zhang1,2, Yang Feng3, Jia Huang1
1Department of Medical Genetics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
International journal of biometeorology
|August 21, 2024
概括
怀孕早期高温会增加先天性心脏病 (CHD) 的风险,特别是心室隔膜缺陷 (VSD) 和心房隔膜缺陷 (ASD). 特定的孕期窗口显示了对极端温度的高度脆弱性.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 心血管研究研究心血管研究
背景情况:
- 大气温度与先天性心脏病 (CHD) 之间的联系尚不清楚.
- 了解环境对胎儿发育的影响至关重要.
研究的目的:
- 调查每周暴露于温度和心脏病风险之间的关联.
- 为了确定与温度相关的CHD发展的脆弱妊娠期.
主要方法:
- 基于人口的回顾性病例控制研究.
- 分析了643例心血管疾病病例和3215例对照病例.
- 分布滞后非线性模型 (DLNM) 和二进制物流回归.
主要成果:
- 第一个三个月升高的体温与整体心血管疾病和血管疾病风险的增加有关.
- 第二个三个月的温度升高与更高的ASD风险相关.
- 观察到非线性温度-CHD关系;极端高温 (5-11,23-27周) 和极端寒冷 (13-14周对于ASD) 显示出显著的关联.
结论:
- 在特定的孕期期间的极端温度对心脏病,包括VSD和ASD构成风险.
- 研究结果强调了气候变化对先天性心脏缺陷的影响.
- 进一步的研究需要专利的动脉管和Fallot的四分法.
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