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铜在动物中的毒性:一篇评论

Yudong Wang1, Qiushi Yan1, Yang Shi1

  • 1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang, 110866, China.

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PubMed
概括

过多的铜摄入会对细胞和器官造成损害,从而导致动物的毒性. 了解铜代谢和毒性机制对于制定有效的预防和治疗策略至关重要.

关键词:
动物疾病 动物疾病铜的积累 铜的积累铜的恒常性是铜的恒常性.铜的毒性 铜的毒性

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科学领域:

  • 兽医医学 兽医医学 兽医医学
  • 毒理学 毒理学 毒理学
  • 生物化学 生化学

背景情况:

  • 铜是必需的,但过量有毒,导致动物组织和器官中的积累.
  • 铜毒性机制包括氧化应激,线粒体功能障碍,亡,自和亡.
  • 越来越多的动物铜毒性病例与环境污染和料补充剂过度使用有关.

研究的目的:

  • 提供对铜在动物中的毒性进行全面的审查.
  • 阐明铜离子代谢和细胞毒性的机制.
  • 讨论关于铜毒性的最新临床和实验发现.

主要方法:

  • 关于铜毒性和代谢的科学出版物的文献综述.
  • 分析最近的临床病例和动物实验.
  • 综合有关预防和治疗措施的信息.

主要成果:

  • 铜离子通过亡,自和亡诱导细胞死亡,特别是通过影响三碳酸 (TCA) 循环蛋白.
  • 铜毒性表现为组织和器官损伤,在动物群体中发生率越来越高.
  • 了解铜代谢是减轻毒性的关键.

结论:

  • 充分了解铜的毒性和代谢对于制定有效的预防策略至关重要.
  • 这一审查是预防和管理动物中铜毒性的参考.
  • 需要进一步的研究来应对铜毒性管理的挑战.