在肠球菌性尿路感染中的线索利德:一个多中心研究
Léa Malinowski1, Souheil Zayet2, Myriam Chiaruzzi3
1Department of infectious and tropical diseases, Besançon University Hospital, Besançon, F-25000, France.
概括
利尼佐利德在治疗肠球菌性尿路感染 (e-UTI) 方面表现出良好的疗效和安全性. 这项研究发现,在接受linezolid治疗e-UTI的患者中,治疗失败率低,不良事件最小.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 肠球菌性尿路感染 (e-UTI) 具有挑战性的治疗方法.
- 关于linezolid对e-UTI的有效性存在有限的数据.
- 了解治疗结果对于患者管理至关重要.
研究的目的:
- 用linezolid治疗的e-UTI患者的特征.
- 评估linezolid在治疗e-UTI中的疗效.
- 评估linezolid在e-UTI中的安全性和耐受性.
主要方法:
- 在5家法国医院进行了观察性,多中心,回顾性研究.
- 包括已确认肠球菌性尿路感染的患者 (≥18岁) 和超过48小时的linezolid治疗.
- 主要结局是临床失败;收集了有关患者特征,治疗和结果的数据.
主要成果:
- 包括81名患者 (平均年龄73岁);E. faecium (80%) 和E. faecalis (32%) 是常见的病原体.
- 没有鉴定出抗万科米辛的肠球菌.
- 莱涅佐利德治疗 (平均13天) 显示临床失败率低 (2.5%) 和少数,非严重的不良事件.
结论:
- 莱涅佐利德是肠球菌性尿路感染的有效和安全的治疗选择.
- 这项研究提供了有价值的现实世界的证据,支持在这种适应症中使用linezolid.
- 进一步的研究可能会探索最佳持续时间和特定的患者子组.
关键词:
菌 (Enterococcus faecalis) 是一种菌.肠球菌 (Enterococcus faecium) 是一个有毒的菌株.肠球菌 (Enterococcus) 是一个细菌.线索化物 线索化物尿路感染 尿路感染更多相关视频
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