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对轮状病毒疫苗的间接保护:系统性审查

Tyler Chavers¹, Jordan Cates¹, Eleanor Burnett¹

¹Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Expert review of vaccines

|August 21, 2024

概括

罗塔病毒疫苗通过减少疾病传播提供间接保护. 这次对71项研究的审查发现了这种效应的一致证据,特别是在幼儿中.

科学领域:

免疫学免疫学免疫学
公共卫生公共卫生
流行病学流行病学

背景情况:

罗塔病毒疫苗对于减少疾病负担至关重要.
接种疫苗的间接保护可以减少人口内的疾病传播.

研究的目的:

系统地审查和综合估计由轮状病毒疫苗提供的间接保护.
检查用于评估这种间接保护的方法.

主要方法:

进行了2009年至2022年间发表的71项研究的系统审查.
分析了399个间接保护的估计值,重点关注5岁以下未接种疫苗的儿童的住院和轮状病毒阳性率等结果.

主要成果:

审查发现,轮状病毒疫苗提供了显著的间接保护.
在未接种疫苗的5岁以下儿童中,住院病例的中位发病率比为0.60.
轮状病毒阳性和病例数的中位相对百分比变化分别为25%和42%.

结论:

罗塔病毒疫苗证明了广泛的间接保护.
标准化结果措施,指标,年龄组和疫苗引入以来的时间是必要的,以便进行一致的评估.

关键词:

群体保护群体保护间接保护间接保护疫苗的间接保护是通过疫苗的间接保护.轮状病毒病毒的病毒.疫苗疫苗疫苗疫苗

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