循环胺剂对患有结缔组织疾病的儿科患者卵巢功能障碍的影响:系统范围审查
Ken-Ei Sada1,2, Takako Miyamae2,3, Kayoko Kaneko2,4
1Department of Clinical Epidemiology, Kochi Medical School, Nankoku, Japan.
Modern rheumatology
|August 21, 2024
概括
环胺 (CY) 在儿童期用于结缔组织疾病的使用没有明确的临床影响卵巢功能. 然而,包括卵泡刺激激素 (FSH) 在内的荷尔蒙特征可能会受到影响,这需要进一步的研究.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 生殖内分泌学 生殖内分泌学
- 药理学 药理学是指药理学的学科.
背景情况:
- 青少年发病的结缔组织疾病 (JCTD) 通常需要免疫抑制治疗.
- 环胺 (CY) 是一种常用于治疗JCTD的化剂.
- 儿童CY暴露对生殖健康的潜在长期影响是一个重大问题.
研究的目的:
- 系统地审查有关儿童周期胺剂对JCTD患者卵巢功能影响的现有文献.
- 确定和综合有关临床卵巢功能障碍,激素概况和卵巢储备的发现.
主要方法:
- 对MEDLINE数据库进行了全面的系统范围审查.
- 搜索词包括环胺,青少年开始的结缔组织疾病和卵巢功能.
- 在经过两阶段查过程后,纳入了6项以系统性红斑狼患者为重点的观察性研究.
主要成果:
- 包括的研究显示,由于缺乏对混变量进行调整,混偏差的风险很高.
- 在CY暴露和非CY暴露组之间没有观察到临床卵巢功能障碍的明显差异.
- 在CY暴露的患者中,统计差异表明卵巢储量下降和卵泡刺激激素 (FSH) 水平升高.
结论:
- 目前的证据表明,在儿童时期使用环胺可能不会对卵巢功能产生明确显著的临床影响.
- 需要进一步的研究来了解CY对荷尔蒙水平,生育能力和怀孕结果的影响.
- 该审查强调需要仔细监测儿童期接受CY治疗的JCTD患者的生殖健康状况.
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