慢性背痛发展期间边缘大脑结构的灰质体积:一个纵向队列研究
Nicola Neumann1, Martin Domin, Martin Lotze
1Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.
Pain
|August 21, 2024
概括
慢性背痛 (CBP) 与皮质膜区域的大脑结构变化有关. 在CBP患者的灰质体积变化表明这些大脑变化可能是慢性疼痛的风险因素和驱动因素.
科学领域:
- 神经科学是一个神经科学.
- 医学成像医学成像
- 疼痛研究 疼痛研究
背景情况:
- 慢性背痛 (CBP) 是一种普遍存在的疾病,具有复杂的潜在机制.
- 了解疼痛慢性化的神经生物学基础对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究背痛慢性化和大脑皮质膜结构中的灰质结构变化之间的关系.
- 为了检查慢性背痛和没有慢性背痛的个体灰质体积 (GMV) 的纵向变化.
主要方法:
- 基于人口的纵向队列研究.
- 磁共振成像 (MRI) 用于测量灰色物质体积 (GMV) 在两个7年间隔的时间点.
- 慢性背痛参与者 (n=168) 与无疼痛对照者 (n=323) 的比较.
主要成果:
- 患有慢性背部疼痛的参与者在7年内,左腹条形体的GMV增加,左侧海马上回形体的GMV减少.
- 在慢性背部疼痛组中,较长的疼痛持续时间与左尾骨的GMV下降相关.
- 新出现的慢性背部疼痛与右侧内区域,右桃体和左侧中枢前皮层的GMV减少有关.
结论:
- 边缘大脑的特性似乎涉及到既使个体易患慢性背痛,又推动大脑在发育过程中的重组.
- 皮质膜区域的灰质结构变化与背痛的慢性化有关.
- 这些发现强调了大脑在应对慢性疼痛条件时的神经可塑性.
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