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Updated: May 5, 2026

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
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PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

Published on: July 3, 2010

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活细胞中小分子RNA结合部位的全转录组映射协议

Yuquan Tong1, Patrick R A Zanon2, Xueyi Yang1

  • 1The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA; The Scripps Research Institute, Department of Chemistry, 130 Scripps Way, Jupiter, FL 33458, USA.

STAR protocols
|August 21, 2024
PubMed
概括

这项研究引入了一项新的协议,用于绘制小分子如何与细胞和体外RNA相互作用. 这种方法有助于通过可视化它们在RNA上的分子指纹来识别潜在的候选药物.

关键词:
生物物理学的生物物理.化学 化学 化学分子/化学探头 分子/化学探头

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Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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