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与甲状腺手术抗生素预防相关的好处和风险
Samuel D Squires1, Robin M Cisco2, Dana T Lin2
1Brigham Young University, Provo, Utah.
The Journal of surgical research
|August 21, 2024
概括
预防性抗生素 (pABX) 通常在甲状腺手术前给予,但这项研究没有发现与手术部位感染 (SSI) 的减少有任何联系. 在甲状腺切除术中停止实施常规的pABX可能是有益的.
科学领域:
- 手术瘤学手术瘤学
- 预防传染病 预防传染病
- 临床结果研究研究的临床结果.
背景情况:
- 预防性抗生素 (pABX) 经常在甲状腺手术前使用,尽管手术被归类为干净.
- 甲状腺切除术中PABX的必要性和有效性仍然是研究的主题.
研究的目的:
- 评估预防性抗生素使用与手术部位感染 (SSI) 发生率在接受甲状腺切除术的患者之间的关联.
主要方法:
- 一项队列研究包括了在2010年至2019年期间接受甲状腺手术的成年患者.
- 倾向性得分匹配用于控制影响SSI风险的患者人口统计和并发症.
- 主要结局是30天的SSI,通过诊断代码和/或抗生素使用来确定.
主要成果:
- 在2411名患者中,56.3%接受了pABX,通常具有更高的并发症得分.
- 在pABX组中,未调整的SSI发生率更高 (6.1%对3.4%).
- 在倾向分数匹配后,pABX使用与30天整体SSI或需要干预的SSI风险降低无关.
结论:
- 预防性抗生素使用与在接受甲状腺手术的大型并发症队列中降低SSI发病率无关.
- 这些发现表明,常规的pABX在甲状腺切除术中可能具有低价值.
- 应考虑在甲状腺手术中停止使用预防性抗生素,以优化患者护理和资源配置.
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