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无塑性甲状腺癌的死亡率趋势:我们有没有取得进展?
Bosung N Titanji1, Michelle Earley2, Electron Kebebew2
1Department of Surgery, Stanford University, Palo Alto, California; Meharry Medical College School of Medicine, Nashville, Tennessee.
The Journal of surgical research
|August 21, 2024
概括
尽管有新的治疗方法,但无塑性甲状腺癌的生存率在全国范围内没有得到改善. 然而,接受任何治疗的患者的癌症特异性存活率增加,突出显示需要更有效的疗法.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 无塑性甲状腺癌 (ATC) 的死亡率很高,导致三分之二的甲状腺癌死亡.
- 对于ATC的中位生存时间大约为6个月,即使使用多模式治疗.
- 最近的单中心研究表明,使用新的ATC治疗方法可以改善生存率.
研究的目的:
- 调查新的ATC治疗方法和多式联运方法是否与随着时间的推移减少国家死亡风险有关.
- 分析甲状腺癌的全国生存趋势.
主要方法:
- 从国家癌症研究所的SEER数据库 (1990-2020) 中分析了874名无塑性甲状腺癌患者.
- 利用考克斯的比例危险模型来评估2年生存率的变化,并确定与生存相关的特征.
- 评估了整体生存率 (OS) 和癌症特定生存率 (CSS).
主要成果:
- 整体2年生存率为14%,癌症特异性生存率为19%.
- 从1990年到2020年,随着诊断年数的增加,没有观察到CSS的显著变化 (aHR 0.98 [0.94, 1.01]).
- 接受治疗 (手术,化疗,辐射) 的患者显著增加了CSS (aHR 0.42 [0.32, 0.55]).
结论:
- 经过对混因素进行调整后,在全国范围内随着时间的推移,没有发现对甲状腺无塑性癌症的整体或癌症特异性生存率的显著改善.
- 虽然接受治疗与改善的CSS有关,但更有效的疗法对于增加存活率至关重要.
- 进一步研究新的和改进的ATC治疗策略是有必要的.
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