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Updated: Jun 15, 2025

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
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通过氧化还原触发的二硫化物裂解来加强RNA修饰和CRISPR-Cas活性的控制

Huajun Lei1, Wei Xiong1, Ming Li1

  • 1College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, The Institute of Molecular Medicine, Wuhan University People's Hospital, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan 430072, Hubei, China.

Bioorganic & medicinal chemistry
|August 21, 2024
PubMed
概括

研究人员开发了一种使用修改指导RNA (gRNA) 的条件基因编辑的新方法. 这种氧化还原触发系统允许在体内精确控制CRISPR-Cas基因编辑应用程序.

关键词:
克里斯普尔系统是克里斯普尔系统.可控制的RNA修饰不硫化物裂变的裂变转毒催化剂的触发器小分子分子 小分子分子

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