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药理疗法针对动脉样硬化的免疫反应

Yirong Wu¹, Yizhou Xu¹, Linhao Xu²

¹Department of Cardiology, Hangzhou First People's Hospital, 310006 Zhejiang, China.

International immunopharmacology

|August 21, 2024

概括

动脉样硬化 (AS) 涉及免疫细胞加速斑块的形成. 本综述探讨了免疫细胞在AS中的作用,目前的治疗方法,以及管理这种慢性炎症疾病的未来治疗潜力.

科学领域:

免疫学免疫学免疫学
心血管医学心血管医学
药理学药理学是指药理学的学科.

背景情况:

动脉样硬化 (AS) 是一种慢性炎症性疾病.
免疫细胞如中性粒细胞,单细胞,巨细胞,B细胞和T细胞是AS斑块形成的关键驱动因素.
这些细胞影响炎症,脂质代谢和泡细胞的发展,加速疾病的进展.

研究的目的:

阐明激活免疫细胞促进动脉样硬化的机制.
审查针对AS治疗免疫细胞激活的现有临床试验.
确定当前治疗策略的局限性,并探索新的治疗途径.

主要方法:

关于免疫细胞参与AS的科学文献的综述.
对针对免疫路径的AS治疗方法发表的临床试验数据的分析.
对新型化合物的临床前研究的评估,包括草药和饮食因素.

主要成果:

激活的免疫细胞对动脉样硬化的发病有显著的贡献.
目前的临床试验在有效抑制AS治疗免疫细胞激活方面存在局限性.
新型化合物在动物模型中显示出缓解AS的治疗前景.

结论:

了解免疫细胞机制对于开发有效的AS疗法至关重要.
针对免疫系统诱导的炎症具有治疗动脉样硬化的巨大潜力.
需要进一步的研究和临床试验,以将新的治疗策略转化为临床实践.

关键词:

激活免疫细胞的免疫细胞被激活.适应性免疫细胞适应性免疫细胞动脉样硬化是一种动脉样硬化.草药是一种草药.炎症反应是一种炎症反应.形成斑块的形成.

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