伴随性疼痛和阿片类药物使用障碍中的性别差异:范围审查
Elise E DeVito1, Victoria Ameral2,3, Mehmet Sofuoglu1,4
1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
British journal of clinical pharmacology
|August 21, 2024
概括
本综述强调了阿片类药物使用障碍 (OUD) 和慢性疼痛中的性别/性别差异. 研究结果表明,不同的生物和心理社会因素影响了它们的同时发生和治疗,强调了需要量身定制的方法.
科学领域:
- 医学研究 医学研究
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物使用障碍 (OUD) 和慢性疼痛经常同时发生,可能会相互恶化.
- 现有的研究表明,OUD和慢性疼痛的临床表现和生物基础存在性别/性别差异.
研究的目的:
- 进行范围审查,总结有关OUD和慢性疼痛交叉点的性别/性别差异的现有文献.
- 确定性别/性别如何影响OUD和慢性疼痛同时发生的发展和治疗.
主要方法:
- 系统地搜索同行评审的关于人类主题的文章,这些文章涉及OUD,慢性疼痛和性别/性别差异.
- 从最初的146篇识别论文中包括30篇研究.
- 慢性疼痛,阿片类药物滥用/OUD以及样本,预测因素和结果的性别/性别变量的主题图表.
主要成果:
- 大多数纳入的研究是横截面的,性别/性别分析往往是后期的.
- 初步发现表明,男性的OUD患病率更高,女性的慢性疼痛更高.
- 有证据表明,在影响OUD和慢性疼痛发展和治疗的生物和心理社会因素中,存在潜在的性别/性别差异.
结论:
- 性别和性别是理解OUD和慢性疼痛之间的相互作用的关键因素.
- 未来的研究应该优先研究性/性别特异性机制和治疗策略,用于同时发生的OUD和慢性疼痛.
- 根据性别/性别量身定制干预措施可能会改善两种情况的个体的结果.
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