认知功能,自杀念头和自杀企图在严重抑郁症,双相情感障碍,精神分裂症和相关疾病中的关联:系统性审查和元分析
Gia Han Le1, Sabrina Wong2, Sipan Haikazian3
1Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Canada.
Journal of affective disorders
|August 21, 2024
概括
认知缺陷与主要抑郁症 (MDD) 和精神分裂情绪障碍中自杀风险有关. 了解心理健康状况的这种联系对于自杀预防策略至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 精神障碍如严重抑郁症 (MDD),双相情感障碍 (BD) 和精神病障碍是自杀风险的重要贡献者.
- 这些情况往往伴随着神经认知缺陷,影响一个人的功能能力.
研究的目的:
- 调查认知功能与自杀念头/自杀企图 (SI/SA) 之间的关联.
- 在被诊断患有精神分裂情绪障碍,BD和MDD的个体中分析这种关系.
主要方法:
- 在PubMed,Ovid和Scopus数据库中进行了系统的文献搜索.
- 发表在2024年4月之前的研究被包括在内,如果它们报告了认知-SI/SA协会的效果大小.
- 一个随机效应模型被用于对41项纳入研究的元分析.
主要成果:
- 在精神分裂情绪障碍和MDD中,执行功能和SI/SA之间发现了负相关性.
- 对双相情感障碍的结果是混合的,显示了与全球执行功能的积极关联以及与情绪抑制的负面关联.
- 处理速度,注意力,学习和记忆在各种诊断中显示出不同的结果.
结论:
- 在主要精神障碍中,认知功能和自杀倾向之间存在跨诊断的关联.
- 认知障碍,特别是以奖励为基础的功能,冲动控制,计划和工作记忆的认知障碍,可能是自杀倾向的基础.
- 需要进一步的研究,承认研究样本和认知措施的异质性.
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