在新生儿缺氧-缺血症后,乳酸盐的使用会导致长期的神经保护作用
Isadora D'Ávila Tassinari1, Janaína Zang1, Nícolas Heller Ribeiro2
1Departamento de Fisiologia, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2600, Porto Alegre 90035-003, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Federal University of Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2600, Porto Alegre 90035-003, Brazil; Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Ramiro Barcelos, 2350, Porto Alegre, RS 90035-903, Brazil.
Experimental neurology
|August 21, 2024
概括
乳酸在低氧缺血症 (HI) 后的新生小鼠中显示出神经保护作用. 这种治疗减少了脑损伤,并改善了两性感官运动和认知功能,这表明治疗新生儿HI的潜力.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 儿科 儿科 儿科
背景情况:
- 新生儿缺氧缺血症 (HI) 是新生儿死亡率和残疾的主要原因.
- 目前的治疗,治疗性低温症,有局限性.
- 乳酸是大脑发育的关键代谢燃料,可以提供神经保护.
研究的目的:
- 在新生儿HI的老鼠模型中研究乳酸剂的神经保护潜力.
- 评估乳酸治疗对HI暴露大鼠脑损伤和行为结果的长期影响.
主要方法:
- 新生Wistar大鼠 (P7) 接受了缺氧-缺血症 (HI) 或虚假手术.
- 乳酸盐或载体是在HI后通过腹膜内注射的.
- 在不同年龄段进行了行为测试 (负地质测试,正确反射,圆柱体测试,开放场地,新型物体识别).
- 大脑损伤的体积被评估为P60.
主要成果:
- 乳酸盐的使用显著降低了HI大鼠的大脑病变的体积.
- 乳酸治疗改善了从新生儿到成人阶段的感觉运动和认知行为.
- 这些有益影响在雄性和雌性大鼠中都被观察到.
结论:
- 乳酸盐的使用显示出对HI诱导的大脑损伤和功能缺陷的显著神经保护作用.
- 乳酸盐可能是新生儿缺氧缺血症的一个有前途的治疗策略.
- 对乳酸作为新生儿HI治疗的进一步研究是有必要的.
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