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月经阶段对通过间歇性甲基突破刺激诱导的突触可塑性的影响

K R Ramdeo¹, F C Adams¹, C C Drapeau¹

¹Department of Kinesiology, McMaster University, 1280, Main Street West Hamilton, Ontario L8S 4L8, Canada.

|August 21, 2024

概括

在女性中,间歇性甲爆刺激 (iTBS) 诱导的神经可塑性在月经周期中各不相同. 毛囊期iTBS增加了运动唤起的潜能,而质期iTBS没有,这表明激素对大脑可塑性的影响.

科学领域:

神经科学是一个神经科学.
生殖内分泌学生殖内分泌学

背景情况:

卵巢激素显著影响神经可塑性.
已知雌激醇可以增强短期可塑性.
孕激素对rTMS诱导的可塑性的影响尚不清楚.

研究的目的:

调查月经周期阶段对间歇性甲基突破刺激 (iTBS) 诱导的短期可塑性的影响.
测试iTBS是否会在卵泡阶段增加运动唤起潜力 (MEP).
探索质阶段对iTBS诱导的神经可塑性的影响.

主要方法:

29名女性接受了安慰剂对照研究,在左主运动皮层进行了真实和假的iTBS.
会议在卵泡和质阶段进行,再加上假条件.
在iTBS之前和之后测量了皮层脊髓刺激能力 (MEPs,SICI).

主要成果:

真正的iTBS在卵泡阶段显著增加了MEP振幅.
在形或假条件下,没有观察到MEP振幅的显著变化.
短期内皮层抑制 (SICI) 仍然不受iTBS的影响.

结论:

妇女在iTBS诱导的短期神经可塑性中表现出依赖月经周期的变化.
这些发现对于优化女性基于rTMS的治疗策略至关重要.
在月经周期中的荷尔蒙波动会影响大脑的可塑性.

关键词:

毛囊的毛囊是如何形成的卢泰尔 (luteal) 是一种乳糖.卵巢激素卵巢激素卵巢激素突触性可塑性突触性可塑性在ITBS的ITBS系统中.rTMSMS是因为

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