在心力衰竭中夜间心律不整,与阻塞性和中央睡眠呼吸暂停有关
Christian M Horvath1, Christoph Fisser2, John S Floras3
1Sleep Research Laboratories of the University Health Network, Toronto Rehabilitation Institute (KITE) and Toronto General Hospital and University of Toronto, Toronto, ON, Canada; Department of Medicine, University Health Network and Sinai Health and University of Toronto, Toronto, ON, Canada.
Chest
|August 21, 2024
概括
患有心力衰竭,排泄率减少 (HFrEF) 和睡眠呼吸暂停 (OSA或CSA) 的患者,夜间心律不整的发病率较高. OSA的严重程度与心房外门症负担相关.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和中心睡眠暂停 (CSA) 与夜间心律不整 (NCAs) 有关.
- 有限的数据存在于心力衰竭的NCA患病率与减少喷射率 (HFrEF) 患者与OSA或CSA.
研究的目的:
- 为了比较HFrEF患者患有OSA,CSA和无/轻度睡眠呼吸暂停的NCA患病率.
- 评估OSA/CSA严重程度与心房/心室NCAs之间的关联.
主要方法:
- 使用HFrEF患者的多睡眠图心电图的ADVENT-HF试验的辅助研究.
- 在OSA,CSA和对照组中比较的NCAs (过度的脑膜外皮活动[ESVEA],心房动/动[AF],每小时>10个过早心室复合体[PVCs]).
主要成果:
- 在OSA (9%) 和CSA (12%) 和对照 (0%) 中,ESVEA流行率较高.
- 肌肉前的患病率:9% (对照组),17% (OSA),27% (CSA) 的患者.
- >10 PVC/h 的流行率: 45% (对照组), 59% (OSA), 63% (CSA).
- 与早发性心房复合体增加相关的OSA严重程度/小时 (P=.009).
结论:
- 患有OSA或CSA的HFrEF患者的夜间ESVEA,AF和PVC的发病率更高.
- OSA的严重程度与夜间心房外皮症负担有关.
- 在OSA/CSA严重程度和AF或频繁的PVC之间没有发现显著的关联.
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