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优化超声波参数,以开发含有维生素D3的阿拉伯糖纳米乳液 - - 一种维生素D3强化方法

Iqra Bashir¹, Sajad Mohd Wani¹, Nusrat Jan¹

¹Division of Food Science and Technology, Sher-e-Kashmir University of Agricultural Sciences and Technology, Kashmir, Jammu and Kashmir 190025, India.

International journal of biological macromolecules

|August 21, 2024

概括

使用阿拉伯糖纳米乳液封装维生素D3显著提高了其生物可用性和稳定性. 优化条件产生了具有改善食品和制药应用特性的纳米乳液.

科学领域:

食品科学食品科学食品科学
材料科学材料科学材料科学
化学工程是化学工程的重要组成部分.

背景情况:

维生素D的生物可用性,稳定性和溶解性通常是有限的.
封装技术为克服这些局限性提供了一个有希望的解决方案.

研究的目的:

开发和优化一个高效的纳米乳液维生素D3封装使用阿拉伯糖.
为了评估制造的纳米乳液的物理化学特性和释放动力学.

主要方法:

选各种生物聚合物 (乳清蛋白分离物,碳氧甲基纤维素,酸盐,阿拉伯) 用于维生素D3封装.
使用Box-Behnken设计优化纳米乳液配方,以超声波波幅,超声波时间和维生素D3/壁材料比为因素.
纳米乳液颗粒大小,泽塔潜力,封装效率和化学相互作用 (DSC,FTIR) 的表征.
使用Korsmeyer-Peppas模型分析维生素D3释放动力学.

主要成果:

阿拉伯因其优越的性能而被选为最佳的墙体材料.
优化条件 (80%的超声波振幅,12分钟的超声波,5%的维生素D3/壁材料) 产生了具有20.04nm颗粒大小,-28.2mV泽塔电位和71.9%封装效率的纳米乳液.
不同扫描热度计和FTIR证实了纳米乳液内的化学相互作用.
科尔斯迈耶-佩帕斯模型最好地描述了维生素D3释放特征.

结论:

基于阿拉伯糖的纳米乳液为维生素D3封装提供了一种有效的方法.
优化的纳米乳液表现出在食品和制药行业潜在使用的理想特征.
这项研究表明,纳米乳液技术的成功应用改善了维生素D的输送.

关键词:

生物聚合物是一种生物聚合物.这是一种纳米乳液.优化优化优化优化超声波超声波是指超声波的使用.维生素D3 维生素D3 是一种维生素.

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