相关实验视频

Updated: Jun 15, 2025

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques

Published on: August 23, 2024

辅溶剂对以基为基础的菌混合物的特性的影响:对皮肤输送的影响

Grzegorz S Czyrski¹, Thomas Rades¹, Andrea Heinz¹

¹LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.

International journal of pharmaceutics

|August 21, 2024

概括

将辅助溶剂添加到以基为基础的浸泡剂混合物中,可以增强克洛特里马的通过皮肤递送和保留,同时减少皮肤损伤. 这些混合物的性能优于传统的溶剂,如烯基醇或乙醇.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
皮肤病学皮肤病学

背景情况:

基于烯的欧混合物 (EMs) 显示出由于增强的溶解性和角层 (SC) 相互作用,它对通过皮肤传递药物具有前途.
辅溶剂 (CSs) 对电磁特性的影响及其与传统溶剂 (如基醇 (PG) 和乙醇 (EtOH) 进行透皮输送) 的比较仍未得到充分研究.

研究的目的:

研究EM:CS混合物中的辅溶剂含量对克洛特里马 (CLOT) 通过皮肤输送的影响.
为了比较这些混合物与纯EM和CS的性能.
为了评估EMs中的基数比对皮肤透的影响.

主要方法:

以基为基础的欧性混合物 (menthol:thymol,thymol:β-citronellol) 在不同的摩尔比率,包括欧性点的配方.
使用PG和EtOH作为不同度的辅溶剂制备EM:CS混合物.
评估克洛特里马的溶解性和皮肤透度的增强.
使用显微镜或其他相关技术评估角层 (SC) 的结构完整性.

主要成果:

与单个EM或CS相比,EM:CS混合物表现出较高的克洛特里马溶解度.
混合物中增加的CS含量与增强的CLOT皮肤透和保留相关.
较高的CS度导致SC结构的破坏减少.
在它们的学点上,EMs显示的透概况不如预期的最佳,这表明单个烯特性是关键.

结论:

将辅助溶剂添加到以基为基础的浸泡剂混合物中,显著改善了克洛特里马的通过皮肤透和保留.
与纯基系统相比,这些优化的混合物提供了较低的皮肤损伤潜力.
该研究强调了EM:CS混合物的潜力,作为通过皮肤递送药物的有效和更安全的平台.

关键词:

克洛特里马 (Clotrimazole) 是一种药物.欧性混合物欧性混合物角质层 (Stratum corneum) 是一个层.烯是一种烯.通过皮肤传递的输送.在X射线中,散射是X射线的散射.

更多相关视频

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Preparation of Binary and Ternary Deep Eutectic Systems

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

相关概念视频

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Physical Properties of Ethers

Physical Properties of Ethers

Overview
An ether molecule has a net dipole moment due to the polarity of C–O bonds. Subsequently, boiling points of ethers are lower than those of alcohols of comparable molecular weight and slightly higher than those of hydrocarbons of comparable molecular weight (Table 1).
Ethers can act as hydrogen bond acceptors, making them more water-soluble than hydrocarbons, but since ethers cannot act as hydrogen bond donors, they are much less soluble in water than alcohols. Ethers are considered...

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH

Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...

Solvating Effects

Solvating Effects

An understanding of the solvating effect helps rationalize the relation between solvation and acidity of the compound. In addition, this also explains the relative stability of conjugate bases for compounds with different pKa values. This lesson details, in-depth, the principle of solvating effects. The strength of an acid and the stability of its corresponding conjugate base are determined using pKa values. This observed relationship is a consequence of solvation, which is the interaction...