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较低的痛苦不耐受与青少年大麻使用者中较高的谷氨水平有关

Punitha Subramaniam¹, Andrew Prescot², James Yancey³

¹Diagnostic Neuroimaging Laboratory, University of Utah, Salt Lake City, UT 84108, USA; Department of Psychiatry, Huntsman Mental Health Institute, University of Utah School of Medicine, Salt Lake City, UT 84108, USA.

Pharmacology, biochemistry, and behavior

|August 21, 2024

概括

青少年大麻使用者具有较低的大脑谷氨 (抗氧化剂) 水平,显示出更大的痛苦不耐受性. 这表明氧化压力与大麻使用者无法应对压力之间的联系.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
生物化学生物化学

背景情况:

大麻 (CB) 使用和心理压力会增加大脑的氧化压力.
谷氨 (GSH) 是一种关键的大脑抗氧化剂,可以保护大脑免受氧化应激.
压力不耐受是CB使用的危险因素,但其与大脑GSH的联系尚不清楚.

研究的目的:

调查前带皮质 (ACC) 中大脑谷氨酸 (GSH) 水平与青少年大麻使用者的痛苦不耐受性之间的关系.
为了比较青少年大麻使用者和健康对照者 (HC) 之间的GSH水平和痛苦不耐受性.

主要方法:

在ACC中使用代谢物编辑质子磁共振光谱 (3T扫描仪) 评估GSH水平.
使用苦难不容忍指数 (DII) 测量了苦难不容忍.
通过17名CB用户和16名HC的结构化临床访谈评估CB使用情况.

主要成果:

在大麻使用者中,较低的ACCGSH水平与较高的DII分数相关.
在大麻使用者和HC之间没有发现ACCGSH或DII得分的显著差异.
在HC组中没有观察到GSH和DII之间的显著相关性.

结论:

在大麻使用者中,较低的GSH和更大的痛苦不耐受之间的关联可能表明氧化应激平衡发生了变化.
研究结果表明,大麻使用,氧化应激和痛苦不耐受性之间存在潜在的神经生物学联系.
进一步的研究可以为大麻使用障碍的预防和治疗策略提供信息.

关键词:

青少年青少年青少年大麻大麻大麻大麻大麻大麻大麻压力不容忍症压力不容忍症葡萄糖氨酸 (Glutathione) 是一种磁共振光谱学磁共振光谱学

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