新出现的双A替代品的不良结果
Nina Franko1, Anja Kodila1, Marija Sollner Dolenc1
1University of Ljubljana, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.
Chemosphere
|August 21, 2024
概括
人们越来越担心含有替代品的"无BPA"产品,如双甲类似物 (BPA) 和替代品,因为它们的安全性在很大程度上没有得到评估. 这些化学物质对人类和野生动物构成毒理风险,需要进一步的安全评估.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 由于已知的有害影响,双A (BPA) 和其类似物面临着越来越多的监管限制.
- 为了规避这些法规,新型BPA类似物和替代品正在被引入消费品中,包括塑料,头和热纸.
- 这些BPA替代品的安全性在市场推出前往往没有得到充分的评估,这引发了对"无BPA"产品的担忧.
研究的目的:
- 综合整理有关选择的BPA替代品和替代品的信息.
- 为了说明这些化合物的潜在毒性.
- 确定BPA替代品和替代品的关键安全数据缺口.
主要方法:
- 审查和对现有数据进行对比,这些数据来自于in silico,in vitro和in vivo研究.
- 对监管机构对安全数据不足的化合物的认可进行分析.
- 在消费品,食品和环境中存在的BPA替代品和替代品的识别.
主要成果:
- 众多BPA类似物和替代品 (例如BPAP,BPS-MAE,BTUM,PF201) 被认为没有足够的安全数据.
- 这些化合物存在于消费品,食品和环境中,具有毒理学风险.
- 研究表明,BPA类似物会破坏内分泌系统,损害生殖功能,并引起肝毒性和行为改变等影响.
- 对于BPA替代品的体外和体外数据很少,尽管in silico研究预测了潜在的不良影响.
结论:
- 在消费品和环境中存在BPA的替代品和替代品,具有显著的毒理风险.
- 现有关于BPA类型的数据表明它具有内分泌干扰性和其他不良健康影响.
- 许多BPA替代品的安全数据严重缺乏,尽管它们被广泛使用,这突显了进一步研究和监管监督的迫切需要.
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