患有IPF的患者营养不良的患病率和预后值使用三种评分系统
Qinxue Shen1, Shiting Zhou1, Min Song1
1Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China; The Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, 410011, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, 410011, China.
营养不良在异形性肺纤维化 (IPF) 患者中普遍存在,并与较高的死亡率有关. 营养状况评估对于预测IPF的结果至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 临床营养学 临床营养学
- 医学统计 医学统计
背景情况:
- 异形性肺纤维化 (IPF) 是一种进展性肺病,具有显著的发病率和死亡率.
- 营养状况越来越被认为是影响IPF疾病进展和患者结果的关键因素.
- 关于IPF患者营养不良的患病率和预后影响的数据有限.
研究的目的:
- 通过验证的评分系统,评估IPF患者的营养状况.
- 确定营养状况和IPF之间的临床关联.
- 评估营养状况在预测IPF死亡率方面的预后价值.
主要方法:
- 分析了2011年至2021年间诊断的264名IPF患者的队列.
- 用营养风险指数 (NRI),控制营养状况 (CONUT) 评分和预后营养指数 (PNI) 来评估营养状况.
- 进行了统计分析,包括多变量分析,以确定与死亡率的关联.
主要成果:
- 营养不良患病率根据指数有所不同: 37.5% (NRI),47.4% (CONUT) 和6.4% (PNI).
- 在10.2%至31.1%的患者中发现了中度至严重的营养不良.
- 无论使用何种指数,营养状况的恶化都与所有原因和IPF特定死亡率的增加有显著联系.
结论:
- 营养不良是IPF患者的常见发现.
- 诊断时的基线营养状况是IPF死亡率增加的强有力的预测指标.
- 营养评估应纳入IPF的管理,以评估预后.
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