饮食中氧化植物对大鼠脂质代谢的影响
Tomonari Koyama1, Daichi Fukuoka1, Kyoichi Osada1
1Department of Agricultural Chemistry, School of Agriculture, Meiji University.
在大鼠血和肝脏中检测到食氧化植物 (OPS). 与植物醇不同,OPS减少了肝脏脂肪合成和改变了脂质新陈代谢,这表明它在肝脏脂质调节中的作用.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 毒理学 毒理学 毒理学
背景情况:
- 实验室研究表明氧化植物 (OPSs) 是有毒的.
- 在体内OPSs对脂质代谢的影响仍然不清楚.
研究的目的:
- 为了研究OPS在老鼠中的生物可用性.
- 为了比较饮食中的植物 (PSs) 和OPS对大鼠脂质代谢的影响.
主要方法:
- 给大鼠施加OPS以评估生物可用性.
- 鼠被食含有PS或OPS的饮食4周.
- 分析了脂质代谢标记物,基因表达和固醇分泌.
主要成果:
- OPS被吸收到大鼠的血和肝脏中.
- 饮食OPS降低了肝脂肪酸合成酶活性和肝脏三糖醇水平.
- OPS调节HMG-CoA减少酶,CYP27A1,NPC1L1和Δ6脱酶的mRNA表达,影响胆固醇和脂肪酸代谢.
- 便中的醇分泌在OPS组中是最高的.
结论:
- 饮食OPS是生物可用的,并显著改变了大鼠的脂质代谢.
- OPS影响肝脏脂质合成,胆固醇调节和脂肪酸脱.
- 需要进一步的研究来了解OPS对脂质代谢的体内影响.
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