尾的分化良好的神经内分泌瘤:诊断,差异和疾病进展
Pooja Navale1, Raul S Gonzalez2
1Department of Pathology, Washington University in St Louis, St Louis, MO, United States.
Seminars in diagnostic pathology
|August 21, 2024
概括
尾的分化良好的神经内分泌瘤 (NETs) 是常见的,并具有特定的显微特征. 瘤大小是分期和转移风险的关键因素,指导治疗决策从尾切除术到血液切除术.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 分化良好的神经内分泌瘤 (NETs) 是最常见的尾瘤.
- 诊断包括世界卫生组织 (WHO) 的分级和美国癌症联合委员会 (AJCC) 的分期.
- 粗略地说,这些瘤可以是微妙的或作为黄色结节存在,通常在尾尖.
研究的目的:
- 总结尾 NET 的临床病理特征.
- 讨论诊断标准,分期和差异诊断.
- 根据瘤大小和风险因素审查治疗策略.
主要方法:
- 对组织病理学特征的审查,包括微观形态学和免疫组织化学.
- 应用已建立的分级 (WHO) 和分阶段 (AJCC) 系统.
- 分析瘤大小,淋巴血管入侵和边缘状态作为预后指标.
主要成果:
- 附录NET表现出具有特定细胞学特征的单调细胞的特征性和绳索.
- 瘤大小是pT类别分期的主要决定因素,与转移风险密切相关.
- 小于1厘米的瘤通常用尾切除术治疗;大于2厘米的瘤需要进行半角切除术,中等大小的瘤仍在争论中.
结论:
- 尾NET具有明显的病理特征,主要根据瘤大小进行分期.
- 瘤大小,淋巴血管入侵和边缘状态影响转移潜力.
- 对尾 NET 的治疗决定以大小为指导,对于小瘤进行尾切除术,对于较大的瘤进行尾切除术.
相关概念视频
Appendicitis-II: Diagnostic Studies and Management
72
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
72
Appendicitis-I: Introduction
99
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
99
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
329
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
329
Chronic Pancreatitis II: Collaborative Care
78
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
78
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Endoscopic Procedures V: ERCP
140
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
140


