特拉马多尔对肠道功能的影响:一个随机的,安慰剂控制的试验
Isabelle M Larsen1, Tina Okdahl1,2, Esben Bolvig Mark1,2
1Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.
Basic & clinical pharmacology & toxicology
|August 21, 2024
概括
特拉马多尔是一种弱小的阿片类药物,通过减缓结肠传输和增加便秘症状,导致阿片类药物诱导的肠功能障碍 (OIBD). 这突出了需要管理肠道问题在患者服用特拉马多尔缓解疼痛.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知更强大的阿片类药物会影响胃肠道功能.
- 作为一种较弱的阿片类药物,特拉马多尔对胃肠道的影响尚不清楚.
- 阿片类药物诱导的肠功能障碍 (OIBD) 是阿片类止痛药的常见副作用.
研究的目的:
- 调查特拉马多尔是否会导致阿片类药物诱导的肠功能障碍 (OIBD).
- 评估特拉马多尔对胃肠道通行,运动和症状的影响.
主要方法:
- 一项随机的,安慰剂控制的研究,涉及20名健康男性参与者.
- 参与者接受延长释放特拉马多尔 (200毫克/天) 或安慰剂10天.
- 胃肠道过渡,运动和水分含量使用3D过渡系统和MRI进行测量. 每天记录肠道排便和症状.
主要成果:
- 与安慰剂相比,特拉马多尔显著延长了结肠传输时间 (34小时 vs 25小时).
- 特拉马多尔增加了小肠的运动性和水分含量.
- 特拉马多尔减少了每天的肠道排便,增加了便的稳定性,并加剧了消化不良和便秘等胃肠道症状. 40%的参与者符合便秘标准,而安慰剂组的比例为0%.
结论:
- 特拉马多尔治疗与阿片类药物诱导的肠功能障碍 (OIBD) 有关.
- 便秘和其他肠道症状应优先考虑在患者治疗特拉马多尔.
- 需要进一步研究对特拉马多尔诱导的OIBD的管理.
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