优化治疗术后抑郁症时使用石胺:对腹腔镜减肥手术患者的综合研究
Jiabao Dai1, Yanfeng Lu1, Zhiqing Zou1
1Department of Anesthesiology, the NO.2 People's Hospital of Changzhou Affiliated to Nanjing Medical University, Changzhou, China.
在麻醉之前服用埃斯基坦胺 (ESK) 显著降低了术后抑郁症状,并增加了来自大脑的神经营养因子 (BDNF) 水平,与麻醉后的服用不同.
科学领域:
- 麻醉学 麻醉学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在治疗术后抑郁症方面,关于埃斯基他的疗效存在相互矛盾的证据.
- 麻醉对大脑功能的影响表明,埃斯基坦胺的时间非常重要.
- 之前的研究表明,亚麻醉剂埃斯基坦胺对治疗耐药抑郁症有效.
研究的目的:
- 为了研究与麻醉相对的esketamine定时对术后抑郁症的影响.
- 为了确定手术前或手术后的乙胺剂是否会影响抑郁症得分和BDNF水平.
主要方法:
- 120名经历了腹腔镜减肥手术的患者被随机分为三个组:麻醉前 (Pre-ESK),麻醉后 (Post-ESK) 和安慰剂.
- 乙胺 (0.2 mg/kg) 是通过静脉注射的.
- 使用患者健康问卷-9 (PHQ-9) 评分来评估抑郁症,并测量了血大脑衍生神经营养因子 (BDNF) 水平.
主要成果:
- 与ESK后和安慰剂组相比,ESK前组在术后第一天显示出明显较低的PHQ-9分数和抑郁症发病率/严重程度.
- 血BDNF水平在Pre-ESK组明显高于其他两个组.
- 在PHQ-9得分和血BDNF水平之间观察到负相关性.
结论:
- 麻醉后的埃斯基坦胺可以缓解腹腔镜减肥手术后的术后抑郁症症状.
- 在治疗手术后抑郁症方面,手术前使用斯基他胺剂比手术后使用更有效.
- 麻醉药物显著影响esketamine治疗术后抑郁症的疗效.
更多相关视频
07:54Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
05:42Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
相关概念视频
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Antidepressant Drugs: MAOIs and Other Agents
Parenteral Anesthetics: Overview
Electroconvulsive Therapy
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Stages of General Anesthesia
