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在多囊卵巢综合征的对手协议中,在新鲜胚胎移植后,构建活产的预测模型

Suqin Zhu^1,2, Xiaojing Chen¹, Rongshan Li¹

¹Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou City, 350001, Fujian Province, China.

Journal of assisted reproduction and genetics

|August 21, 2024

概括

这项研究确定了年龄,BMI和激素水平等关键因素,这些因素会影响PCOS患者接受新鲜胚胎移植的妇女的活产率. 开发了一种预测性诺姆图,以帮助个性化试管婴儿治疗策略.

科学领域:

生殖内分泌学生殖内分泌学
不孕症研究不孕症研究
临床数据分析临床数据分析

背景情况:

多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响生育能力.
在体外受精 (IVF) 周期中新鲜胚胎移植 (FET) 是PCOS相关不孕症的标准治疗方法.
在试管婴儿中经常使用对手协议,以防止过早排卵.

研究的目的:

为了确定影响PCOS患者活产结果的因素,PCOS患者接受FET与对抗剂协议.
开发一种用于临床决策和PCOS患者进行试管婴儿的个性化治疗的预测性名录.

主要方法:

对1242名PCOS患者进行FET与对抗剂协议的回顾性队列研究.
使用Boruta算法和多变量后勤回归分析数据以确定风险因素.
使用ROC曲线,校准曲线和决策曲线分析构建和验证了一个预测性名图.

主要成果:

活产的关键预测因素包括女性年龄,BMI,不孕症持续时间,血清丸激素和孕激素水平在hCG日.
转移的高质量的裂解阶段胚胎的数量和类型也是重要的因素.
开发的名图表显示出良好的区分能力 (AUC 0.804-0.807) 和临床实用性.

结论:

女性年龄,不孕期,BMI,荷尔蒙水平和胚胎质量对于接受FET的PCOS患者活产成功至关重要.
预测性诺米图为预后和个性化试管婴儿治疗规划提供了显著的准确性和临床实用性.

关键词:

在试管婴儿受精体外受精.活生生的出生是活生生的出生.这个名字叫做Nomogram.多囊性卵巢综合征多囊性卵巢综合征预测模型是一个预测模型.

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