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Updated: Jun 15, 2025

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51
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Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51

Published on: February 13, 2019

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人类的Shu复合物通过调节ssDNA上的RPA动态来促进RAD51活动

Sarah R Hengel1,2, Katherine G Oppenheimer3, Chelsea M Smith3,4

  • 1University of Pittsburgh, School of Medicine, Department of Pharmacology and Chemical Biology, UPMC-Hillman Cancer Center, Pittsburgh, PA, USA. sarah.hengel@tufts.edu.

Nature communications
|August 21, 2024
PubMed
概括

包括SWSAP1-SWS1在内的Shu复合体稳定了RAD51细丝,用于DNA修复. 这种复合体对于高保真性修复至关重要,并呈现出潜在的癌症治疗点.

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