在小型平台上测定血清肌的色度测定,使用色调和值空间分析
E Alperay Tarim1, H Cumhur Tekin2,3
1Department of Bioengineering, Faculty of Engineering, Izmir Institute of Technology, Gülbahçe Campus, Block E, Room K1-36, Urla/Izmir, 35430, Türkiye.
Scientific reports
|August 21, 2024
概括
一个新的,低成本的微型系统可以使用智能手机图像处理进行精确的,远程血清肌素测量. 这项创新为慢性病 (CKD) 管理提供了可访问的临床检测.
科学领域:
- 生物医学工程 生物医学工程
- 临床化学 临床化学
- 临床诊断 临床诊断 临床诊断 临床诊断
背景情况:
- 慢性病 (CKD) 对全球的健康和经济造成了重大负担.
- 目前的血清肌素测试需要长时间的等待和复杂的设备,限制了及时诊断.
- 需要可访问,自动化和负担得起的方法来远程监测CKD.
研究的目的:
- 开发和验证用于精确测量血清肌素的小型系统.
- 使用基于智能手机的图像处理进行定量分析.
- 提供低成本的,点的护理解决方案,用于CKD诊断和管理.
主要方法:
- 一个小型系统与集成加热器用于血清肌素分析.
- 在微型储水池芯片中使用了Jaffe方法.
- 采用基于智能手机的图像处理在色调和值 (HSV) 颜色空间.
主要成果:
- 在血清中达到~0.4 mg/dL的检测极限和~1.3 mg/dL的量化极限.
- 基于智能手机的HSV彩色空间分析显示,其性能优于光谱法.
- 该系统提供了一个低成本的替代方案,每台设备87美元,测试成本约为0.5美元.
结论:
- 开发的小型化系统和智能手机处理使得分散的功能测试成为可能.
- 这项技术有可能显著改善CKD诊断和患者护理,特别是在资源有限的环境中.
- 为广泛查和监测慢性病提供了具有成本效益的解决方案.
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