大脑体积和皮质厚度以及与极度早产儿童认知的关联
Hedvig Kvanta1, Nelly Padilla2, Daniela Nosko3
1Department of Women's and Children's Health, Karolinska Institute, Solna, Stockholm, Sweden. hedvig.kvanta@ki.se.
Pediatric research
|August 21, 2024
概括
非常早产的孩子 非常早产的孩子
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 放射学 放射学是一门学科.
背景情况:
- 极度早产 (EPT) 出生与大脑发育的改变和较低的认知功能有关,与按期出生的婴儿相比.
- 关于EPT群体中特定的大脑认知关联的研究有限.
研究的目的:
- 为了研究EPT儿童的大脑体积,皮质厚度和体积增长,与按期出生的对照进行比较.
- 探索神经成像发现与EPT儿童12岁认知结果之间的关系.
主要方法:
- 脑部MRI扫描是在EPT儿童和分娩对照中在相当年龄和/或10岁时获得的.
- 在12岁时进行认知评估.
- 对EPT儿童的长度数据从术期到10年进行了分析.
主要成果:
- 在EPT和对照组中,在10年脑容量和认知结果之间发现了积极的关联.
- 在两组中,在10年皮质厚度和认知结果之间观察到负面关联.
- 10年后的岛屿体积与EPT儿童的认知结果有积极的关联.
结论:
- 10岁的大脑结构与认知功能有关,与EPT和满期出生的儿童相似.
- 岛屿体积可以作为EPT个体认知结果的潜在生物标志物.
- 需要进一步的研究来了解EPT群体中大脑体积增长和认知之间的联系.
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