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Updated: Jun 15, 2025

In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy
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In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy

Published on: December 20, 2021

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自堆叠的小分子用于超敏感的,无基质的Raman成像 in vivo

Shuai Gao1, Yongming Zhang2, Kai Cui2

  • 1School of Pharmacy & Minhang Hospital, State Key Laboratory of Molecular Engineering of Polymers, Key Laboratory of Smart Drug Delivery Ministry of Education, Fudan University, Shanghai, China.

Nature biotechnology
|August 21, 2024
PubMed
概括

一种新的堆叠诱导电荷转移增强拉曼散射 (SICTERS) 技术使用自堆叠分子进行超敏感的体内成像. 这种无基质的方法克服了与传统的表面增强拉曼散射 (SERS) 探针相关的生物安全问题.

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Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
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