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开发透皮配方,整合聚合物基固体微针和热敏凝Fucoidan用于抗衰老:概念验证研究
Frederika Tangdilintin1, Alghifary Anas Achmad1, Stephanie1
1Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Langmuir : the ACS journal of surfaces and colloids
|August 22, 2024
概括
这项研究开发了一种具有固体微针的新型热敏凝,用于输送富可伊丹 (FUC),以对抗皮肤衰老. 该系统有效地提供FUC,显示出有前途的抗衰老潜力和生物相容性.
科学领域:
- 皮肤学和材料科学 皮肤学和材料科学
- 生物材料和药物输送系统
背景情况:
- 紫外线 (UV) 辐射通过降解原蛋白和减少酶活性,导致皮肤光衰老.
- 富科伊丹 (FUC) 具有抗衰老特性,但由于其高分子量而面临着交付挑战.
- 需要有效的局部输送系统来利用FUC的皮肤益处.
研究的目的:
- 开发和评估一种与固体微针 (SMN) 集成的新型热敏凝 (TRG),用于增强Fucoidan (FUC) 的皮肤输送.
- 在动物模型中评估FUC载TRG-SMN系统在预防紫外线诱导的皮肤衰老方面的有效性.
主要方法:
- 使用Pluronic F127和F68制造TRG;使用PVA,PVP和交叉连接器制造SMN.
- 活体皮肤透研究,以量化FUC传递效率.
- 在体外血液溶解测定用于生物相容性评估.
- 在老鼠体内紫外线诱导的皮肤衰老模型,以评估抗衰老效果.
主要成果:
- 优化的TRG-FUC-SMN系统实现了超过80%的FUC输送ex vivo.
- 在体外试验表明TRG-FUC-SMN配方的良好的生物相容性.
- 与对照人群相比,体内研究显示皮肤组织学,弹性,纹和水分的显著改善.
结论:
- 集成的TRG-SMN系统提供了一种有效的方法,可以将FUC送入皮肤.
- 这种新型的输送系统显示出对抗皮肤光衰老和促进皮肤健康的巨大潜力.
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