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化疗会影响儿童一般胸部手术后病理性痕的发展
Xinwei Cheng1, Jiaxi Huang2, Shengzhou Shan1
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
概括
化疗可以减少胸部手术后儿童的病理性痕. 术后化疗显示与外科手术期间治疗相比,痕的风险较低.
科学领域:
- 儿科手术 儿科手术
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 病理性痕严重影响儿童的身体和心理健康.
- 在儿科患者中有效的痕管理是有限的.
- 化疗是治疗成人病理性痕的标准治疗方法,但其在儿童的疗效尚未得到充分研究.
研究的目的:
- 研究化疗对儿科患者病理性痕形成的影响.
- 评估化疗在儿童胸部手术后预防或减少痕方面的作用.
- 为儿科瘤学中痕管理策略提供临床证据.
主要方法:
- 对102名接受胸部手术的儿童 (≤18岁) 进行了回顾性队列研究.
- 2018年1月至2021年12月期间收集的数据.
- 逆概率加权 (IPTW) 逻辑双项回归模型用于分析病理性痕发生率和相关症状 (疼痛,).
主要成果:
- 在接受化疗 (16.7%) 的儿童中,与未接受化疗 (29.4%,p=0.027) 的儿童相比,观察到病理性痕的统计显著减少.
- 手术后的化疗与患病性痕的相对风险较低 (19.8%),而不是手术前治疗 (28.8%).
结论:
- 辅助化疗,特别是在手术后,可能会降低儿科患者病理性痕的发生率.
- 化疗是治疗儿童病理性痕的潜在途径.
- 进一步的研究是有必要的,以优化化疗方案,以预防小儿手术患者的痕.
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