提高先天性心脏缺陷的分类,以获得相关研究的结果,研究出生缺陷的注册表
Sara B Stephens1,2, Renata H Benjamin1, Keila N Lopez2
1Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Birth defects research
|August 22, 2024
概括
对于先天性心脏缺陷 (CHDs) 的新分类系统,核心心脏损伤结果分类 (C-CLOC),通过根据临床相似性分组CHD并保持样本大小以进行更好的分析来改善结果研究.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 公共卫生监督 公共卫生监督
- 临床信息学 临床信息学
背景情况:
- 使用注册数据的传统先天性心脏缺陷 (CHD) 分组方法缺乏临床结果特异性.
- 现有的分类没有充分考虑联合CHDs的不同临床后果.
研究的目的:
- 引入一种新的,病变特定的分类系统,核心心脏病损伤结果分类 (C-CLOC),用于使用出生缺陷注册数据进行心脏病结果研究.
- 证明C-CLOC在改善临床同质性和分析能力方面的实用性.
主要方法:
- 根据常见的CHD和预期的临床同质性定义了C-CLOC组.
- 使用疾病控制中心修改的英国儿科协会 (BPA) 代码为C-CLOC组分配建立了标准.
- 利用德克萨斯州出生缺陷登记数据 (1999-2017年) 来比较C-CLOC和传统分类之间的病例数和新生儿死亡率.
主要成果:
- 在C-CLOC系统中,对于62,262名婴儿,C-CLOC系统定义了59个不同的CHD组.
- 在C-CLOC中重新分类到最复杂的CHD导致了更同质的组.
- 与单个病变分类相比,C-CLOC组保持了更大的样本大小,提高了分析能力.
结论:
- C-CLOC分类系统为基于CHD注册的研究提供了更好的临床结果均性和分析能力.
- 预计该系统将促进更强大的CHD特定结果的比较.
- 未来的研究将利用C-CLOC进行先进的结果关联研究.
相关概念视频
Genome-wide Association Studies-GWAS
13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.2K
Imaging Studies for Cardiovascular System II:Types of Echocardiography
238
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
238
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Imaging Studies for Cardiovascular System III: X-Ray
160
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
160


