随着异常收缩后的骨肌肉适应并非由质素18介导
Muni Swamy Ganjayi1,2, Samuel W Frank3, Thomas A Krauss1
1Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|August 22, 2024
概括
素18 (Krt18) 似乎对骨肌肉适应异常运动训练并不重要. 肌肉强度和恢复在Krt18淘汰和野生类型小鼠中是相似的,这表明Krt18对运动诱导的重塑并不关键.
科学领域:
- 运动生理学 运动生理学
- 骨肌肉生物学 骨肌肉生物学
- 肌肉适应的分子机制
背景情况:
- 奇特的运动训练会诱导复杂的肌肉适应,而这些适应会受到诸如年龄等因素的影响.
- 细胞骨蛋白质氨酸18 (Krt18) 在异常收缩后升高,在年轻的肌肉中含量更高.
- 以前的研究表明,在训练后的年轻肌肉和老肌肉中,基因和蛋白质反应有所差异.
研究的目的:
- 调查素18 (Krt18) 在调解异常运动后骨肌肉适应中的作用.
- 为了确定Krt18的缺失是否会影响肌肉强度和异常收缩后的恢复.
主要方法:
- 使用Krt18淘汰赛 (KO) 和野生型 (WT) 鼠标模型.
- 前部部肌肉遭受一次性和反复的异常收缩.
- 评估异度扭矩以测量肌肉力量和适应能力.
主要成果:
- 在Krt18 KO和WT小鼠之间没有观察到基线肌肉强度或同度扭矩的显著差异.
- 在Krt18 KO和WT小鼠之间,异常运动后的肌肉力量缺陷和恢复是可比的.
- 缺少Krt18并没有妨碍肌肉适应反复异常收缩的能力.
结论:
- 蛋白18 (Krt18) 不是骨肌肉适应异常运动训练所必需的.
- 这些发现表明Krt18在运动诱导的肌肉重塑中没有显著的作用.
- 骨肌中Krt18的低表达可能解释其在运动适应中的有限作用,突出显示肌肉可塑性的复杂性.
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