针对胃癌治疗的肠道微生物群:系统性审查
Amir Marashi1, Saina Hasany2, Sadra Moghimi1
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Frontiers in medicine
|August 22, 2024
概括
肠道细菌显著影响癌症治疗的有效性. 通过益生菌调节肠道微生物组,有望改善癌症患者的治疗结果,特别是胃癌患者.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 临床前研究揭示了细菌对癌症治疗结果的影响.
- 临床研究表明微生物组调节在癌症治疗中的潜力.
- 本综述系统地分析了肠道微生物与化疗和免疫检查点抑制剂的相互作用.
研究的目的:
- 系统地分析肠道微生物如何与化疗和免疫检查点抑制剂相互作用.
- 专注于肠道细菌对癌症治疗的药理动力学和药理动力学的影响.
主要方法:
- 在科学网,Scopus和PubMed的系统文献搜索到2023年8月.
- 根据题目和摘要对研究进行选,使用Rayyan智能工具.
- 使用JBI批判性评估工具对包含的研究进行质量评估.
主要成果:
- 肠道微生物组的改变与胃癌和癌前病变有关,包括减少多样性和改变细菌丰富性.
- 杆菌感染对胃细菌多样性产生负面影响,在根除后部分恢复.
- 肠道细菌影响癌症治疗反应;较高的乳杆菌丰度与更好的免疫治疗结果和延长无进展的生存相关.
结论:
- 益生菌和有针对性的微生物干预措施在预防癌症和提高治疗疗效方面表现有前途.
- 特定的益生菌组合可以减少炎症并改善胃癌患者手术后的肠道微生物平衡.
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