一项随机,双盲,安慰剂控制,单中心的比较研究,评估Paseolean®在超重/肥胖参与者的安全性和有效性
Shashi Chandrama Singh1, Harshpal Singh1, Muskan Choudhary1
1Research and Development Centre, Ambe Phytoextracts Pvt. Ltd. Pauri Garhwal, Uttarakhand, 246276, India.
Heliyon
|August 22, 2024
概括
通过抑制碳水化合物消化,白色豆提取物Phaseolean®显著降低了超重/肥胖个体的体重和BMI. 1500毫克/天的剂量对体重管理最有效.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- Phaseolean®是Paseolus vulgaris (白色豆) 的标准化提取物,具有已证明的α-氨酶抑制特性.
- 这种特性有助于减肥,延迟碳水化合物消化,减少卡路里吸收.
研究的目的:
- 评估Paseolean®在超重或肥胖个体的体重管理中的安全性和有效性.
- 为了比较两个不同的剂量Phaseolean®与安慰剂的影响.
主要方法:
- 一项随机,双盲,安慰剂控制的研究,涉及66名超重或肥胖的参与者.
- 参与者接受了Phaseolean®每天1500毫克,Phaseolean®每天3000毫克或安慰剂45天.
- 关键指标包括体重,BMI,身体脂肪,皮厚度和周长 (腰部,部,大腿).
主要成果:
- 1500毫克/天的Phaseolean®导致平均体重减轻2.10公斤,而3000毫克/天导致1.94公斤,明显高于安慰剂 (0.13公斤) (p < 0.01).
- 与安慰剂相比,在两个Phaseolean®组中观察到BMI,体脂,皮厚度和周长的显著减少 (p <0.01).
- 1500毫克/天剂量在减肥方面表现出比3000毫克/天剂量更大的有效性.
结论:
- 在超重或肥胖个体中,Phaseolean®是安全有效的支持体重管理的药物.
- 1500毫克/天的Phaseolean®剂量似乎是减肥的最佳剂量.
- 提取物的α-氨酶抑制作用有助于其减肥益处.
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